Paraic Kenny, Director


Research Articles


Emmanuel N, Lofgren KA, Peterson EA, Meier DR, Jung EH, Kenny PA (2018) Mutant GATA3 Actively Promotes the Growth of Normal and Malignant Mammary Cells. Anticancer Research (38)4435-4441 [PDF]

Meier DR, Lofgren KA, Gurda GT, Kenny PA (2018) Adaptation of an amplicon-based human cancer next-generation sequencing panel assay for murine tumors. Analytical Biochemistry 551:26-28 [PDF]

Giricz O, Mo Y, Dahlman KB, Cotto-Rios XM, Vardabasso C, Nguyen H, Matusow B, Bartenstein M, Polishchuk V, Johnson DB, Bhagat TD, Shelloe R, Burton E, Tsai J, Zhang C, Habets G, Greally JM, Yu Y, Kenny PA, Fields GB, Pradhan K, Stanley ER, Bernstein E, Bollag G, Gavathiotis E, West BL, Sosman JA, Verma A (2018) The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma. JCI Insight 3(14):e120422 [PDF]

Yapa KT, Deuis J, Peters AA, Kenny PA, Roberts-Thomson SJ, Vetter I, Monteith GR (2018) Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sci. 198:128-135.[PDF]


Parsons BM, Meier DR, Gurda GT, Lofgren KA & Kenny PA. Exceptional response to crizotinib in an MET-amplified triple-negative breast tumor. Journal of Clincal Oncology - Precision Oncology [PDF]

Miller JJ, Lofgren KA, Hughes SR, Cash SE & Kenny PA. Genomic analysis of melanoma evolution following a 30-year disease-free interval. Journal of Cutaneous Pathology 44(9):805-808. [PDF]

Burkard ME, Deming DA, Parsons BM, Kenny PA, Schuh MR, Leal T, Uboha N, Lang JM, Thompson MA, Warren R, Bauman J, Mably MS, Laffin J, Paschal CR, Lager AM, Lee K, Matkowskyj KA, Buehler DG, Rehrauer WM, Kolesar J. Implementation and clinical utility of an integrated academic-community regional molecular tumor board. Journal of Clninical Oncology - Precision Oncology [PDF]


Lofgren KA and Kenny PA (2016) An instructive ductal microenvironment is key for efficient in vivo modeling of estrogen receptor positive breast cancer. Translational Cancer Research 5:S2:S360-362 [PDF].

Azimi I, Beilby H, Davis FM, Marcial DL, Kenny PA, Thompson EW, Roberts-Thomson SJ & Monteith GR (2016) Altered purinergic receptor-Ca2+ signaling associated with hypoxia-induced epithelial-mesenchymal transition in breast cancer cells. Molecular Oncology 10(1):166-178 [PDF].


Peterson EA, Jenkins EC, Lofgren KA, Chandiramani N, Liu H, Aranda E, Barnett M, Kenny PA (2015) Amphiregulin is a critical downstream effector of estrogen signaling in ERα-positive breast cancer. Cancer Research 75(22):4830-4838 [PDF].


Chandiramani N and Kenny PA (2014) Comparative analysis of GATA3 mutation profiles between Asian and Western breast cancer patients: Is there really a difference? Cancer 120(17)2778-2779 [PDF].

Zhou ZN, Sharma VP, Beaty, BP, Roh-Johnson M, Peterson EA, Van Rooijen N, Kenny PA, Wiley HS, Condeelis JS and Segall JE (2014) Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo. Oncogene 33(29):3784-3793 [PDF] [Cited by 5].

So PL, Wang GY, Wang K, Chuang M, Chiueh  VC, Kenny PA and Epstein EH (2014) PI3K-Akt signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis. Cancer Prevention Research 7(4):407-17 [PDF].


Peterson EA, Pectasides E, Shabbeer S, Wiechmann L, Sparano JA & Kenny PA. (2013) Evaluation of serum Amphiregulin levels in breast cancer patients and cancer-free controls. Experimental Hematology & Oncology 2(1):25 [PDF].

Miwa HE, Koba WR, Fine EJ, Giricz O, Kenny PA & Stanley P. (2013) Bisected, complex N-glycans and galectins in mouse mammary tumor progression and human breast cancer. Glycobiology 23(12):1477-1490 [PDF] [Cited by 2].

Giricz O, Calvo V, Peterson EA, Abouzeid CM and Kenny PA (2013) TACE-dependent TGF-alpha shedding drives triple-negative breast cancer cell invasion. International Journal of Cancer 133:2587-2595 [PDF] [Cited by 2].

Calvo V and Kenny PA. (2013) Visualizing movement in the tumor microenvironment landscape. Breast Cancer Research 15:301. [PDF]

Curry MC, Peters AA, Kenny PA, Roberts-Thomson SJ and Monteith GR (2013) Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells. Biochem Biophys Res Comm434(3):695-700. [PDF] [Cited by 10]

Bhagat TD, Zhou L, Sokol L, Caceres G, Gundabolu K, Gordon S, Mantzaris I, Gligich O, Yu Y, Bhattacharyya S, Jing X, Polineni R, Tamari R, Bhatia K, Pellagatti A, Boultwood J, Kambhampati K, Steidl U, Stein C, Ju W, Liu G, Kenny PA, List A, Bitzer M and Verma A. (2013) miR-21 mediates hematopoietic suppression in MDS by activating TGF-b signaling. Blood 121(15):2875-81. [PDF] [Cited by 18].

Sparano JA, Ostrer H and Kenny PA (2013) Translating genomic research into clinical practice: Promises and pitfalls. ASCO Educational Book 15-23 [PDF].


Levano KS and Kenny PA (2012) Clarification of the C-terminal proteolytic processing site of human Amphiregulin. FEBS Letters 586(19):3500-2. [PDF] [Cited by 2].

Peterson EA, Shabbeer S and Kenny PA (2012) Normal range of serum Amphiregulin in healthy adult human females. Clin Biochem 43:460-463 [PDF] [Cited by 2].

Giricz O, Reynolds PA, Ramnauth A, Liu C, Wang T, Stead L, Childs G, Shapiro N, Fineberg S, Kenny PA and Loudig O. (2012) Hsa-miR-375 Is Differentially Expressed During Breast Lobular Neoplasia And Promotes Loss Of Mammary Acinar Polarity. Journal of Pathology 226:108-119 [PDF]. [Cited by 29]

Giricz O, Calvo V, Pero SC, Krag DN, Sparano JA and Kenny PA. (2012) GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Research and Treatment 133:607-615 [PDF] [Cited by 17].

Patsialou A, Wang Y, Lin J, Whitney K, Goswami S, Kenny PA and Condeelis JS. (2012). Selective gene expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Research 14(5):139 [PDF] [Cited by 20].

Lee SY, Meier R, Furuta S, Lenburg ME, Kenny PA, Xu R and Bissell MJ (2012) FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. Journal Of Clinical Investigation [PDF] [Cited by 11]

Peters AA, Simpson PT, Bassett JJ, Lee JM, Da Silva L, Reid LE, Song S, Parat MO, Lakhani SR, Kenny PA, Roberts-Thomson SJ and Monteith GR (2012) Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor negative breast cancer. Mol Cancer Therapeutics (10):2158-68. [PDF] [Cited by 14]

Curry MC, Luk NA, Kenny, PA, Roberts-Thomson SJ and Monteith GR. (2012) Distinct regulation of cytoplasmic calcium signals and cell death pathways by different plasma membrane calcium ATPase isoforms in MDA-MB-231 breast cancer cells. J Biol Chem 287(34):28598-28608 [PDF] [Cited by 16]

Falconer C, Kenny PA, Smart CE, Monteith GR, Roberts-Thomson S (2012) Peroxisome proliferator-activated receptor subtypes in mammary gland development and breast cancer. J Cancer Therapeutics & Research 1:14 [PDF] [Cited by 1].


Levano KS, Jung EH and Kenny PA (2011) Breast cancer subtypes express distinct receptor repertoires for tumor-associated macrophage derived cytokines. Biochem Biophys Res Comm 411 107-110 [PDF] [Cited by 9]

Sparano JA, Goldstein LJ, Childs BH, Shak S, Brassard D, Badve S, Baehner FL, Bugarini R, Rowley S, Perez EA, Shulman LN, Martino S, Davidson NE, Kenny PA, Sledge GW and Gray R . (2011) Relationship between quantitative GRB7 RNA expression and recurrence after adjuvant anthracycline chemotherapy in triple negative breast cancer. Clinical Cancer Research 17(22):7194-7203 [PDF] [Cited by 5].

Loudig O, Brandwein-Gensler M, Kim R, Lin J, Isayeva T, Segall JE, Kenny PA and Prystowsky MB (2011) Illumina Whole-Genome DASL Platform: Assessing Its Performance in Formalin-Fixed Paraffin-Embedded Samples and Its Applicability for Identification of Invasion-Related Genes in Aggressive Oral Squamous Cell Carcinoma. Human Pathology 42(12):1911-22 [PDF] [Cited by 13].

Davis FM, Kenny PA, Soo ETL, van Denderen BJW, Thomson EW, Cabot PJ, Parat MO, Roberts-Thomson SJ and Monteith GR. (2011) Remodeling of Purinergic Receptor-Mediated Ca2+ Signaling as a Consequence of EGF-Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells. PLOS One 6(8): e23464 [PDF] [Cited by 18].

McAndrew D, Grice DM, Peters AA, Davis FM, Stewart T, Rice M, Smart CE, Brown MA, Kenny PA, Roberts-Thomson SJ and Monteith GR (2011) ORAI1-mediated calcium influx in lactation and breast cancer. Mol Cancer Therapeutics 10(3):448-60 [PDF] [Cited by 37]


Feng M, Grice DM, Faddy HM, Nguyen N, Leitch S, Wang Y, Muend S, Kenny PA, Sukumar S, Roberts-Thomson S, Monteith G and Rao R (2010) Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors. Cell (143) 84-98 [PDF ][Cited by 78]

Sparano JA, Fazzari M and Kenny PA (2010) Clinical application of gene expression profiling in breast cancer. Surgical Oncol Clinics North America (19):581-606. [PDF] [Cited by 11]

Grice DM, Vetter I, Faddy HM, Kenny PA, Roberts-Thomson SJ, and Monteith GR (2010). The golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231. J Biol Chem 285(48):37458-66 [PDF] [Cited by 20]

Han J, Chang H, Giricz O, Lee GY, Baehner FL, Gray JW, Bissell MJ, Kenny PA and Parvin B. Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture. Plos Computational Biology 6(2) e1000684 [PDF] [Cited by 37]


Chen A, Cuevas I, Kenny PA, Miyake H, Mace K, Ghajar C, Boudreau A, Bissell MJ and Boudreau N (2009). Endothelial cell migration and VEGF expression are the result of loss of breast tissue polarity. Cancer Research 69(16):6721-6729. [PDF] [Cited by 29]


Faddy HM, Smart CE, Xu R, Lee GY, Kenny PA, Feng M, Rao R, Brown MA, Bissell MJ, Roberts-Thomson SJ and Monteith GR (2008). Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochem Biophys Res Commun. 369(3):977-81 [PDF] [Cited by 35]


Kenny PA and Bissell MJ (2007) Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest 117 (2) 337-345 [PDF] [Cited by 175]

Kenny PA (2007) Tackling EGFR signaling with TACE inhibitors: a rational target for metalloproteinase inhibitors in cancer. Expert Opinion on Therapeutic Targets 11(10):1287-1298 [PDF] [Cited by 26]

Kenny PA (2007) 3D extracellular matrix culture models of EGFR signaling and drug response. Biochemical Society Transactions 35(4):665-668 [PDF] [Cited by 16]

Kenny PA (2007) TACE: a new target in EGFR-dependent tumors. Differentiation 75(9) 800-808 [PDF] [Cited by 46]

McBryan J, Howlin J, Kenny PA, Shioda T and Martin F (2007) ERα-CITED1 co-regulated genes expressed during pubertal mammary gland development: implications for breast cancer prognosis. Oncogene 26(44):6406-6419 [PDF] [Cited by 30]

Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW, Gray JW, Bissell MJ (2007) The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Molecular Oncology 1(1) 84-96  [PDF] [Cited by 307]

Lee GY, Kenny PA, Lee EH and Bissell MJ (2007) 3D culture models of normal and malignant breast epithelial cells. Nature Methods 4(4):359-365 [PDF] [Cited by 453]

Kenny PA, Lee GY, and Bissell MJ (2007) Targeting the tumor microenvironment. Frontiers in Bioscience 12:3468-3474 [PDF] [Cited by 117]

Radisky DC, Kenny PA and Bissell MJ (2007) Fibrosis and cancer: Do myofibroblasts come from EMT? J Cell Biochem 101 (4):830-839. [PDF] [Cited by 203]


Fournier MV, Martin KJ, Kenny PA, Xhaja K, Bosch I, Yaswen P and Bissell MJ (2006). Gene expression signature in organized and growth arrested mammary acini predicts good outcome in brest cancer. Cancer Research 66 (14) 7095-7102 [PDF] [Cited by 86]

Kenny PA, Nelson CM, Bissell, MJ (2006) The Ecology of Tumors. The Scientist 20 (4) 30-35 [PDF] [Cited by 11]


Bissell MJ, Kenny PA, Radisky DC (2005) Microenvironmental regulators of tissue structure and tumor progression – The role of matrix metalloproteinases in the loss of tissue polarity and induction of genomic instability. Cold Spring Harbor Symposia in Quantitative Biology Vol LXX 343-356 [PDF] [Cited by 156]

Bascom JL and Kenny PA (2005) Meeting Report - Keystone Symposium: The Role of Microenvironment in Tumor Induction and Progression, Banff, Canada, Feb 5th – Feb 10th 2005. Breast Cancer Research 7: 113-118 [PDF]

Kenny PA, Enver T and Ashworth A (2005) Receptor and secreted targets of Wnt/beta-catenin signaling in mouse mammary epithelial cells. BMC Cancer 5 (1) 3 [PDF] [Cited by 47]


Kenny PA and Bissell MJ (2003) Tumor reversion: Correction of malignant behavior by microenvironmental cues. International Journal of Cancer (107)  688-95 [PDF] [Cited by] [Cited by 238]

Kenny PA and Rizki A (2003) Meeting Report: 42nd Annual Meeting of the American Society for Cell Biology. Breast Cancer Research 5(3):147-53 [PDF] [Cited by 1]


Kenny PA, Enver T and Ashworth A (2002) Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line. BMC Mol Biol. 3(1):13 [PDF] [Cited by 16]


Kenny PA, Liston EM and Higgins DG (1999) Molecular evolution of immunoglobulin and fibronectin domains in Titin and related muscle proteins. Gene (232) 11-23 [PDF] [Cited by 52]



Citation counts courtesy of





Stages of Cancer Development, Chelsea House Publishers (2007) [Amazon]

Read the review of this book from the National Science Teachers Association.


Scientific News Coverage

Article on Paraic's receipt of Eastern Cooperative Oncology Group Translational Research Award in Oncology Times.


Our collaborative work on ORAI1/SPCA2 published in Cell (2010) has been highlighted in Nature Reviews Cancer.


Our work on TACE in breast cancer (J Clin Invest 2007) has been highlighted by both Nature Reviews Cancer and Expert Review of Anticancer Therapy


Public Media Coverage

Our melanoma genomics study highighted in the La Crosse Tribune


Kenny lab featured in Gundersen's Bridges newsletter.


Kenny Lab featured in New York's Irish Echo newspaper


Kelly wins the Horst Schulz Prize in Biochemistry



Differentation, November 2007. Special Issue on Receptor Signaling in Cancer

The Scientist, April 2006, Feature article on Tumor Ecology